Guidelines
for producing Web content
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Eyestrain
Eyestrain is a factor that differentiates on-screen reading from paper reading. Readers report higher fatigue when reading from a screen than from paper. This is a factor that may help explain why Web users tend to scan text rather than read word for word.
In addition, research has found that reading dark letters on a light background is more difficult on the eye than light letters on a dark background.
Differences between reading from paper and on-screen: