Cardiovascular Disease Risk Factors; Metabolic syndrome and diabetes treatment is important for cardiovascular risk control

Copyright 2005, Obesity, Fitness & Wellness Week viaNewsRx.com

Obesity, Fitness & Wellness Week Atlanta:Dec 10, 2005. p. 1443

Treatment of metabolic syndrome and diabetes is important for controlling cardiovascular risk.

"The prevalence of diabetes is increasing worldwide. Insulin resistance and diabetes mellitus are major predictors of cardiovascular ischemic disease," scientists writing in the journal Diabetes Obesity & Metabolism report in their review.

D.E. Rosenberg and colleagues at Thomas Jefferson University described, "Other risk factors for cardiovascular death including hypertension, dyslipidemia, smoking and visceral obesity is especially lethal in diabetics. C-reactive protein, plasminogen activator inhibitor-1, matrix metalloproteinases and other emerging risk factors and their roles are continually being researched and discovered."

"Treatment of this syndrome," proposed the reviewers, "must be aimed at lifestyle modification, glycemic control and management of concomitant risk factors. Diet and exercise play a vital role in the treatment of diabetes and the metabolic syndrome. Weight reduction and increased physical activity will improve insulin resistance, hyperglycemia, hypertension and dyslipidemia.

"Hypertension management has been shown to be especially important in diabetics to prevent cardiovascular events. Likewise, multiple clinical trials show that reduction of cholesterol is even more vital in diabetics than the general population for risk reduction of coronary disease."

They remarked, "There is a great deal of evidence that tight control of glycemia is essential to treatment of this condition. There are a variety of available pharmacological agents available including metformin, insulin secretagogues, alpha-glucosidase inhibitors, thiazolidinediones and insulin. The mechanisms and side effects of these medications are discussed."

"As macrovascular disease is the major cause of morbidity and mortality, an early, aggressive, multifactorial approach to treatment of the metabolic syndrome and diabetes is vital to prevent adverse cardiac outcomes," concluded the authors.

Rosenberg and colleagues published their study in Diabetes Obesity & Metabolism (Insulin resistance, diabetes and cardiovascular risk: approaches to treatment. Diabetes Obes Metab, 2005;7(6):642-653).

Additional information can be obtained by contacting B.J. Goldstein, Thomas Jefferson University, Jefferson Med College, Division Endocrinol Diabetes & Metab Diseases, Dept. Med, Suite 349, 1020 Locust St., Philadelphia, PA 19107, USA.

The publisher of the journal Diabetes Obesity & Metabolism can be contacted at: Blackwell Publishing, 9600 Garsington Rd., Oxford OX4 2DQ, Oxon, England.

Keywords: Philadelphia, Pennsylvania, United States, Cardiology, Cardiovascular Disease, Diabetes Mellitus, Endocrinology, Hypertension.

This article was prepared by Obesity, Fitness & Wellness Week editors from staff and other reports. Copyright 2005, Obesity, Fitness & Wellness Week via NewsRx.com.